Kaempferol and Its Glycoside, Kaempferol 7-O-rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro
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چکیده
منابع مشابه
Kaempferol 3-O-rhamnoside-7-O-rhamnoside is an endogenous flavonol inhibitor of polar auxin transport in Arabidopsis shoots
Polar auxin transport (PAT) plays key roles in the regulation of plant growth and development. Flavonoids have been implicated in the inhibition of PAT. However, the active flavonoid derivative(s) involved in this process in vivo has not yet been identified. Here, we provide evidence that a specific flavonol bis-glycoside is correlated with shorter plant stature and reduced PAT. Specific flavon...
متن کاملIn vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca
Previously, we reported that the kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca showed potent anti-HSV activity. In the present study the anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside are investigated at different concentrations (100, 50, 25 and 10 μg/ml) using HIV-1 p24 Antigen kit. Real-time Polymerase chain reaction (RT-PCR) assay was also used...
متن کاملin vitro anti-hiv-1 activities of kaempferol and kaempferol-7-o-glucoside isolated from securigera securidaca
previously, we reported that the kaempferol and kaempferol-7- o -glucoside isolated from securigera securidaca showed potent anti-hsv activity. in the present study the anti-hiv-1 activities of kaempferol and kaempferol-7- o -glucoside are investigated at different concentrations (100, 50, 25 and 10 µg/ml) using hiv-1 p24 antigen kit. real-time polymerase chain reaction (rt-pcr) assay was also ...
متن کاملIn Vivo and in Vitro Hepatoprotective Potential of Kaempferol, a Flavone Glycoside from Capparis Spinosa
This study was designed to investigate in-vivo and in-vitro hepatoprotective activity of kaempferol isolated from Capparis spinosa L. in CCl4 intoxicated rat. Kaempferol is a bioflavonoid reported with antioxidant, antiinflammatory and antiapototic effects which can prevent CCl4 induced hepatic lipid peroxidative damage mediated by oxidative free radical. Kaempferol was isolated from C. spinosa...
متن کاملKaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties.
The objective of this study was to examine the biological activity of kaempferol and its rhamnosides. We isolated kaempferol (1), a-rhamnoisorobin (2), afzelin (3), and kaempferitrin (4) as pure compounds by far-infrared (FIR) irradiation of kenaf (Hibiscus cannabinus L.) leaves. The depigmenting and anti-inflammatory activity of the compounds was evaluated by analyzing their structure-activity...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21093239